Delaminomycins, novel extracellular matrix receptor antagonist. III. Physico-chemical properties and structure elucidation of delaminomycins B and C.

delaminomycin A (1, Fig. 1), a novel compound possessing an acyl tetramic acid moiety1}, has been isolated from the culture broth of Streptomyces albulus MJ202-72F3 which was deposited in the Fermentation Research Institute of the Agency of Industrial Science and Technology, Japan, with the accession No. FERMP-126742). The strain also produced some compounds related to delaminomycin A as minor components. In this paper, we report the physico-chemical properties and structural elucidation of two components, delaminomycins B (2, Fig. 1) and C (3, Fig. 1). These compounds 2 and 3 also inhibited the binding of Con A stimulated-EL4 cells to FN and LMcomponents of ECM2).